Our lab has been intensely focused on the study of the transcriptional profiles of intestinal samples of both ulcerative colitis and Crohn’s disease patients. Whole genome transcriptional analysis has become an instrumental tool to understand and discover new pathological mechanisms as well as to define the molecular features of response or lack of response to different therapeutic strategies.
Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that lead to bowel damage and disability. Despite advancements in the last decade, available treatments do not benefit all patients. This supports the need to uncover, in both UC and CD, relevant unknown pathways sustaining disease activity and promoting refractoriness to existing drugs. Applying single-cell RNA sequencing (sc-RNAseq) to the involved tissues may provide information that can help us identify some of these mechanisms.
Thanks for your visit. Copyright © 2022 IBD Lab. All rights reserved.