Hospital Clinic of Barcelona & IDIBAPS

Inflammatory Bowel Disease Unit

A major referral center dedicated to discovering mechanisms with direct therapeutic implications for IBD.

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About Us

The Inflammatory Bowel Disease (IBD) Unit combines clinicians and investigators from the Hospital Clinic of Barcelona with researchers at IDIBAPS. We serve the metropolitan area of Barcelona, Spain.

Our projects are directed toward the characterization of differential patterns of immune response in early and late Crohn’s Disease (CD) and Ulcerative Colitis (UC). We utilize advanced methodologies including transcriptomics and spatial single-cell technologies to unravel complex disease mechanisms.

In the area of therapeutics, the main focus of the group is the development of innovative forms of cell therapies.

Spatial Biology
Transcriptomics
Cell Therapy

Latest Projects

Garrido-Trigo et al.

Macrophage heterogeneity at single-cell spatial resolution.

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Melon-Ardanaz et al.

Tofacitinib response mechanisms in Ulcerative Colitis.

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Gudiño et al.

TL1A-activated T cells in Perianal Fistulising Disease.

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Newsletter & Publications

Stay updated with our latest findings. Click to read the full papers.

2025
TL1A-activated T cells remodel the rectal mucosa

Published in Gut. Identifying predisposing events driving fistula formation.

2025
Mechanisms of lack of response to Tofacitinib

Published in Journal of Crohn's and Colitis (JCC). Myeloid hyperactivation contributes to resistance.

2024
Macrophage and neutrophil heterogeneity in IBD

Published in Nature Communications. Single-cell spatial resolution analysis.